Biophotonics : vibrational spectroscopic diagnostics / Matthew J. Baker, Caryn S. Hughes, Katherine A. Hollywood.

"Version: 20160201"--Title page verso.

"A Morgan & Claypool publication as part of IOP Concise Physics"--Title page verso.

Includes bibliographical references.

1. Introduction : the measurement interface between physical and life sciences -- 2. Infrared spectroscopy -- 2.1. Fundamentals of an IR spectrum -- 2.2. IR micro-spectroscopy -- 2.3. Attenuated total reflectance

3. Raman spectroscopy -- 3.1. Fundamentals of Raman spectroscopy -- 3.2. The Raman spectrometer -- 3.3. Enhancing the Raman signal

4. Biomedical spectroscopy -- 4.1. Measurement process -- 4.2. Sample preparation -- 4.3. Spectral collection -- 4.4. Spectral pre-processing -- 4.5. Data analysis methods -- 4.6. Data feedback requirements

5. Vibrational biomedical spectroscopy of cells -- 5.1. Cells as a model system -- 5.2. The applicability of biomedical spectroscopy -- 5.3. Retrievable information from the analysis of cells -- 5.4. Experimental research focused on sample preparation -- 5.5. Experimental research towards clinical application -- 5.6. Current trends in research -- 5.7. Summary

6. Vibrational biomedical spectroscopy of biofluids -- 6.1. Introduction -- 6.2. Experimental research focused on sample preparation -- 6.3. Experimental research towards clinical application

7. Vibrational biomedical spectroscopy of tissue -- 7.1. Introduction -- 7.2. Experimental research focused on sample preparation -- 7.3. Experimental research towards clinical application -- 7.4. Current trends in research

8. The future is bright -- 8.1. Micro-, nano- and femtofluidics -- 8.2. Intra-operative diagnostics -- 8.3. The diagnostic 'Minority report' -- 8.4. Unleashed from the bench.

Biophotonic diagnostics/biomedical spectroscopy can revolutionise the medical environment by providing a responsive and objective diagnostic environment. This book aims to explain the fundamentals of the physical techniques used combined with the particular requirements of analysing medical/clinical samples as a resource for any interested party. In addition, it will show the potential of this field for the future of medical science and act as a driver for translational across many different biological problems/questions.

Also available in print.

Mode of access: World Wide Web.

System requirements: Adobe Acrobat Reader.

Matthew Baker obtained his PhD from the University of Manchester in the Manchester Interdisciplinary Biocentre. He was awarded an EPSRC Fellowship conducting research at the Robert Koch Institute and Harvard Medical School. He is currently a Senior Lecturer in the Department of Pure and Applied Chemistry, University of Strathclyde. His research aims are to understand the composition and behaviour of molecules within complex matrices related to real-world detection challenges with a specific focus on developing spectroscopic biofluid diagnostics. Caryn Hughes obtained a PhD entitled 'Development of FTIR for Drug Response Analysis' at the University of Manchester in 2011. Caryn has since worked as an interdisciplinary Postdoctoral Research Associate in groups including the Genito Urinary Cancer Research; at the Cancer Research UK Manchester Institute, the Analytical and Medical Vibrational Spectroscopy Group at the Manchester Institute of Biotechnology; the Instrumentation and Analytical Science group at the University of Manchester; and the Bioanalytical Science Research Group (led by Matthew Baker) at the University of Strathclyde. Katherine Hollywood obtained her PhD from the School of Chemistry at the University of Manchester, focusing on using a variety of analytical techniques to investigate the onset of skin disease. Katherine is currently employed as a PDRA on a BBSRC BRIC funded project that aims to use single-cell technologies both spectroscopic- and mass spectrometry-based to investigate cell heterogeneity and differentiation with the aim of detecting and predicting differentiation status. Her research focus continues to use Raman spectroscopy and mass spectrometry-based metabolomics to investigate mammalian systems.

Title from PDF title page (viewed on March 10, 2016).